Total Prostate-Specific Antigen (Total PSA)

A prostate marker used for prostate cancer screening and monitoring.

Last reviewedJune 16, 2026

Serum

sample type

~5 mL

blood needed

~7 days

results in app

Any time of day

best timing

INCLUDED WITH ANIVA

199 € / year

0.55 € a day

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

Prostate-specific antigen, or PSA, is a protein made by the prostate gland. Total PSA measures all the PSA in your blood, both the part that floats freely and the part bound to other proteins.

Small amounts of PSA leak into the bloodstream normally. The level tends to rise with age and with the size of the prostate, and it can go up for many reasons that have nothing to do with cancer.

Cancer Markers (Screening)

Reviewed against DGKL reference practice.

Why test this?

Total PSA is used to follow prostate health over time. A raised level can come from prostate cancer, but far more often it reflects benign causes such as an enlarged prostate (BPH), inflammation, a recent infection, or even a bike ride or sex in the days before the test.

PSA is not a standalone cancer test for the general population. A single value means little on its own. Your doctor reads it alongside your age, the trend over time, a physical exam, and sometimes the free-to-total ratio before deciding whether anything further is needed.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult reference values as used by Aniva. Ranges are guidance and can vary by laboratory and method.

Group	Normal range
Men, age 40 to 49	Below 2.5 µg/L
Men, age 50 to 59	Below 3.5 µg/L
Men, age 60 to 69	Below 4.5 µg/L
Men, age 70 to 79	Below 6.5 µg/L

Sources: Oesterling 1993 PSA age-specific ranges

Your Aniva report reads your result against these values together with your age, sex and the rest of your panel.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

A baseline PSA level you can track over the years.
An early flag that, with your doctor, may prompt a closer look at the prostate.
Context your concierge can pair with the free PSA ratio and your symptoms for a personalized action plan.

What can affect this result?

What can skew the result

Recent ejaculation, cycling, a prostate exam, catheter use, or urinary infection can raise PSA. Drugs such as finasteride and dutasteride roughly halve the level. PSA falls after some prostate treatments. Results from different assays are not always interchangeable.

Best interpreted with

Usually read together with free PSA and the free/total PSA ratio, and alongside a clinical exam.

How is this tested?

Sample

Serum

Blood needed

~5 mL

Method

Immunoassay

Best timing

Any time of day

Sources. The evidence behind this

Mayo Clinic Laboratories: Prostate-Specific Antigen, Serum

StatPearls: Prostate-Specific Antigen

National Cancer Institute: PSA Test

Common questions

Which Aniva panels include this marker?

Cancer and Tumor Screening

These tests measure key tumor markers linked to the most common and serious cancers.