Prostate-Specific Antigen Free/Total Ratio (PSA F/T Ratio)

The ratio of free to total PSA, which helps distinguish benign from malignant prostate disease.

Last reviewedJune 16, 2026

Serum

sample type

~5 mL

blood needed

~7 days

results in app

Any time of day

best timing

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

The PSA free/total ratio is a calculated value, not a separate blood test. It divides free PSA by total PSA and is shown as a percentage.

It exists to add detail when total PSA is borderline. The ratio helps weigh whether a raised PSA is more likely from benign prostate enlargement or from something that needs a closer look.

Cancer Markers (Screening)

Reviewed against DGKL reference practice.

Why test this?

This ratio is most useful when total PSA falls in the grey zone, often 4 to 10 µg/L, and the prostate exam is normal. A higher percentage of free PSA leans toward a benign cause such as BPH. A lower percentage raises the chance of prostate cancer.

The ratio is a probability tool, not a diagnosis. Your doctor uses it together with your age, PSA trend, and exam to decide whether further steps, such as imaging or biopsy, are worth considering.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult reference values as used by Aniva. Ranges are guidance and can vary by laboratory and method.

Group	Normal range
Men	Above 0.25

Sources: Michigan MLabs PSA total/free

Your Aniva report reads your result against these values together with your age, sex and the rest of your panel.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

A clearer read on a borderline total PSA.
Help in separating benign enlargement from higher-risk patterns.
A data point your concierge and doctor can use within a personalized action plan.

What can affect this result?

What can skew the result

Because the ratio depends on both PSA measurements, anything that skews PSA, such as recent ejaculation, cycling, a prostate exam, infection, or 5-alpha-reductase drugs, can affect it. Delayed sample handling lowers free PSA and distorts the ratio. Different assays give different cutoffs.

Best interpreted with

Read together with total PSA, free PSA, and a clinical prostate exam.

How is this tested?

Sample

Serum

Blood needed

~5 mL

Method

Calculated from immunoassay

Best timing

Any time of day

Sources. The evidence behind this

Mayo Clinic Laboratories: Prostate-Specific Antigen, Free and Total

StatPearls: Prostate-Specific Antigen

National Cancer Institute: PSA Test

Common questions

Which Aniva panels include this marker?

Cancer and Tumor Screening

These tests measure key tumor markers linked to the most common and serious cancers.