Cancer Antigen 125 (CA-125)

A tumor marker associated with ovarian cancer.

Last reviewedJune 16, 2026

Serum

sample type

~5 mL

blood needed

~7 days

results in app

Any time of day

best timing

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

Cancer antigen 125, or CA-125, is a protein found on the surface of many cells, including those of the ovary. A small amount circulates in the blood of healthy people.

It is measured as a tumor marker, most often in the context of ovarian conditions, but it is not specific to cancer.

Cancer Markers (Screening)

Reviewed against DGKL reference practice.

Why test this?

CA-125 is used mainly to monitor people already diagnosed with ovarian cancer and to help assess certain pelvic masses, alongside imaging and exam. It is not a screening test for healthy women, because many benign conditions raise it.

Levels can go up with menstruation, endometriosis, fibroids, pelvic inflammation, pregnancy, and liver disease. A raised result is common and usually benign, so it always needs a doctor to interpret in context.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult reference values as used by Aniva. Ranges are guidance and can vary by laboratory and method.

Group	Normal range
Adults	Below 35 kIU/L

Sources: 2016 EGTM Ovarian Biomarker Guideline

Your Aniva report reads your result against these values together with your age, sex and the rest of your panel.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

A baseline CA-125 level, most useful when tracked over time.
An early flag that, with your doctor, may prompt further assessment.
Context your concierge can read alongside your history and symptoms in a personalized action plan.

What can affect this result?

What can skew the result

Menstruation, endometriosis, fibroids, pelvic inflammatory disease, pregnancy, and liver disease can all raise CA-125. Results from different assays are not interchangeable, so trends should be followed on the same method.

Best interpreted with

Read alongside pelvic imaging and clinical exam, and sometimes other markers such as HE4 when assessing a pelvic mass.

How is this tested?

Sample

Serum

Blood needed

~5 mL

Method

Immunoassay

Best timing

Any time of day

Sources. The evidence behind this

Mayo Clinic Laboratories: CA 125, Serum

MedlinePlus: CA-125 Blood Test

Medscape: Gynecologic Tumor Markers

Common questions

Which Aniva panels include this marker?

Cancer and Tumor Screening

These tests measure key tumor markers linked to the most common and serious cancers.