eGFR (Cystatin C)

An estimate of kidney filtration based on cystatin C, independent of muscle mass.

Last reviewedJune 16, 2026

Calculated

sample type

Not applicable (calculated)

blood needed

~7 days

results in app

Any time of day

best timing

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On this page

Why test Reference ranges What you'll learn What affects it How testing works Sources FAQ

In short

eGFR (cystatin C) is an estimate of how well your kidneys filter blood, calculated from the level of cystatin C. Cystatin C is a protein made by all cells at a steady rate and cleared by the kidneys, so its blood level reflects filtration.

The result is a calculated value using a validated equation, usually CKD-EPI, and is reported in mL/min per 1.73 square metres of body surface area.

Kidney Function

Reviewed against DGKL reference practice.

Why test this?

eGFR is the standard way to gauge overall kidney function. The cystatin C version is useful because, unlike creatinine, it is not strongly affected by muscle mass, so it can be more accurate in people who are very muscular, frail, or elderly.

A lower eGFR means slower filtration and reduced kidney function. It is used to stage chronic kidney disease and to track changes over time.

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult reference values as used by Aniva. Ranges are guidance and can vary by laboratory and method.

Group	Normal range	Optimal range
Adults	Above 60 mL/min	Above 90 mL/min

Sources: UKKA Kidney Function, KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Your Aniva report reads your result against these values together with your age, sex and the rest of your panel.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.

What insights will this test give you?

An estimate of your overall kidney filtration.
A measure less affected by muscle mass than creatinine-based eGFR.
A value used to stage kidney function and follow it over time.

What can affect this result?

What can skew the result

Thyroid disease, steroid use, and marked inflammation can affect cystatin C and therefore the estimate. The equation assumes a steady state, so it is less reliable when kidney function is changing quickly. It is an estimate, not a direct measurement.

Best interpreted with

Read alongside cystatin C itself, creatinine-based eGFR, and urine albumin to creatinine ratio.

How is this tested?

Sample

Calculated

Blood needed

Not applicable (calculated)

Method

Calculated

Best timing

Any time of day

Sources. The evidence behind this

LOINC 87430-5: Cystatin C and GFR by Cystatin C-based formula panel

KDIGO: CKD Evaluation and Management Guideline

Mayo Clinic Laboratories: Cystatin C with Estimated GFR

Common questions

Which Aniva panels include this marker?

Cystatin C

These tests assess kidney filtration independent of muscle mass, more accurate than creatinine alone.

eGFR (Cystatin C)

Why test this?

What is a normal result?

What insights will this test give you?

What can affect this result?

What can skew the result

Best interpreted with

How is this tested?

Sources. The evidence behind this

Common questions

Which Aniva panels include this marker?

Related biomarkers usually read alongside this one

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